Description

3-Azabicyclo[3.1.0]Hexane-3-Carboxylicacid,6-Amino-,Methylester is a high-value, nitrogen-containing bicyclic building block with a constrained, rigid scaffold. This compound is a critical intermediate in modern pharmaceutical research and development, prized for its ability to impart specific conformational and pharmacological properties to target molecules. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization programs to explore structure-activity relationships (SAR) due to its unique 3D geometry.
• Process Chemistry & Scale-up: Serves as a starting material or advanced intermediate in the development of scalable synthetic routes for API manufacturing.
• Protease Inhibitor Development: The constrained azabicyclic structure is valuable in designing inhibitors for various enzymatic targets.
• Chemical Biology Probes: Incorporated into molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	3-Azabicyclo[3.1.0]Hexane-3-Carboxylicacid,6-Amino-,Methylester
CAS No.	210165-66-5
Molecular Formula	C8H12N2O2
Molecular Weight	168.19 g/mol
Synonyms	6-Amino-3-azabicyclo[3.1.0]hexane-3-carboxylic acid methyl ester; Methyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate; 3-Azabicyclo[3.1.0]hexane-3-carboxylic acid, 6-amino-, methyl ester; (1R,5S)-6-Amino-3-azabicyclo[3.1.0]hexane-3-carboxylic acid methyl ester (for specific stereoisomer); 3-Azabicyclo[3.1.0]hexane-3-carboxylic acid methyl ester, 6-amino-; 210165-66-5; 6-Amino-3-azabicyclo[3.1.0]hexane-3-carboxylic acid, methyl ester
EINECS	Contact for details

Quality Control

Our 3-Azabicyclo[3.1.0]Hexane-3-Carboxylicacid,6-Amino-,Methylester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay, chiral purity (where applicable), and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. The storage area should be well-ventilated and separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.