Description

4-Chloroindole-2-14C is a carbon-14 labeled derivative of 4-chloroindole, a valuable building block in synthetic organic chemistry. This isotopically labeled compound is essential for conducting advanced metabolic, pharmacokinetic, and environmental fate studies, providing critical data for regulatory submissions and scientific research. It is primarily utilized by pharmaceutical R&D laboratories, agrochemical companies, and specialized contract research organizations (CROs) focused on tracer and analytical chemistry.

Application

• Tracer Studies in Drug Metabolism and Pharmacokinetics (DMPK): Used as a radiolabeled intermediate to synthesize 14C-labeled drug candidates for tracking absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Agrochemical Research: Serves as a key precursor for developing radiolabeled pesticides or herbicides to study their environmental degradation, soil metabolism, and plant uptake pathways.
• Biochemical Pathway Elucidation: Employed in mechanistic studies to trace the incorporation of the indole moiety or chlorinated aromatic systems into more complex natural products or biologically active molecules.
• Reference Standard for Analytical Method Development: Acts as a critical standard in Liquid Chromatography-Mass Spectrometry (LC-MS) or Liquid Chromatography-Radiochemical Detection (LC-RAD) methods for quantifying metabolites or degradation products.
• Synthesis of Radiolabeled Heterocyclic Compounds: Functions as a versatile, labeled starting material for synthesizing a diverse array of 14C-labeled indole derivatives and fused polycyclic systems for various research applications.

Basic Information

Product Name	4-Chloroindole-2-14C
CAS No.	210110-92-2
Molecular Formula	C8H4Cl14CN
Molecular Weight	Contact for details
Synonyms	4-Chloro-1H-indole-2-14C; 2-14C-4-Chloroindole; 4-Chloroindole-2-carbon-14C; 1H-Indole-2-14C, 4-chloro-; 4-Chloro-2-14C-indole; Radiolabeled 4-Chloroindole
EINECS	Contact for details

Quality Control

Every batch of 4-Chloroindole-2-14C is manufactured and analyzed under strict quality systems to ensure identity, purity, and specific activity. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with the stringent requirements for radiolabeled compounds used in regulatory studies. A comprehensive Certificate of Analysis (COA) detailing chemical purity, radiochemical purity, specific activity, and analytical methods is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. Store in accordance with all local and national regulations for radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference
Chemical Purity (HPLC)	≥ 98.0%
Radiochemical Purity (HPLC-RAD)	≥ 97.0%
Specific Activity	Customizable (mCi/mmol)
Solubility	Soluble in common organic solvents (DMSO, methanol, DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.