Description

3-(4-Iodophenyl)-3-(Trifluoromethyl)-3H-Diazirine is a specialized photoaffinity labeling reagent, a critical tool for studying biomolecular interactions. Its unique diazirine ring, activated by UV light, generates a highly reactive carbene intermediate capable of forming covalent bonds with proximal molecules. This compound is essential for researchers and developers in pharmaceutical discovery, chemical biology, and proteomics who require precise mapping of protein-ligand interactions and binding sites.

Application

• Photoaffinity Labeling (PAL): A key reagent for covalent cross-linking in target identification and validation studies.
• Chemical Proteomics: Used to create activity-based probes for profiling enzyme families and drug target engagement.
• Drug Discovery: Employed to identify and characterize small molecule binding sites on proteins and nucleic acids.
• Structural Biology: Aids in the elucidation of three-dimensional protein structures and complex assemblies.
• Material Science: Potential use in surface functionalization and polymer cross-linking via carbene insertion chemistry.

Basic Information

Product Name	3-(4-Iodophenyl)-3-(Trifluoromethyl)-3H-Diazirine
CAS No.	210107-38-3
Molecular Formula	C8H4F3IN2
Molecular Weight	312.03 g/mol
Synonyms	4-Iodophenyl(trifluoromethyl)diazirine; 3-(p-Iodophenyl)-3-(trifluoromethyl)diazirine; 3-(4-Iodophenyl)-3-(trifluoromethyl)diazirine; 3H-Diazirine, 3-(4-iodophenyl)-3-(trifluoromethyl)-; Photoaffinity Labeling Reagent 210107-38-3; p-Iodophenyl trifluoromethyl diazirine; Iodo-PTFMD
EINECS	Contact for details

Quality Control

Our 3-(4-Iodophenyl)-3-(Trifluoromethyl)-3H-Diazirine is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, critical for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability. We adhere to ISO 9001 quality management principles, and our analytical methods (including HPLC, NMR, and MS) are validated to provide reliable data for our global customer base.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at temperatures between 2°C and 8°C (refrigerated) for long-term stability. This compound is light-sensitive (store away from light). Allow the container to reach room temperature before opening to minimize condensation. Keep under inert atmosphere if possible to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline solid or solution
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%
Solvent Content (GC)	As per COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.