Description

2-Amino-1-(trideuteromethyl)-6-phenylimidazo[4,5-b]pyridine is a deuterated derivative of the heterocyclic aromatic amine PhIP, a compound of significant research interest. This deuterium-labeled analog is a critical tool for advanced analytical and metabolic studies, offering enhanced stability and traceability. It is primarily utilized by research institutions and pharmaceutical companies engaged in toxicology, carcinogenesis research, and the development of sophisticated mass spectrometry-based analytical methods.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a stable, isotopically labeled internal standard for the precise quantification of PhIP and its metabolites in complex biological matrices via LC-MS/MS.
• Metabolic Pathway Tracing: Used in pharmacokinetic and metabolic studies to elucidate the absorption, distribution, metabolism, and excretion (ADME) profiles of heterocyclic aromatic amines.
• Toxicology and Carcinogenesis Research: A key reagent in investigating the mechanisms of formation, bioactivation, and DNA adduct formation of food-borne mutagens.
• Analytical Method Development: Essential for developing and validating highly sensitive and specific analytical methods in food safety and environmental monitoring laboratories.
• Reference Material: Provides a certified reference material for quality control and assurance programs in analytical testing.

Basic Information

Product Name	2-Amino-1-(trideuteromethyl)-6-phenylimidazo[4,5-b]pyridine
CAS No.	210049-13-1
Molecular Formula	C13H10D3N4
Molecular Weight	230.28 g/mol
Synonyms	2-Amino-1-(methyl-d3)-6-phenylimidazo[4,5-b]pyridine; [D3]-PhIP; PhIP-d3; 2-Amino-1-(trideuteriomethyl)-6-phenyl-1H-imidazo[4,5-b]pyridine; Deuterated PhIP; 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-d3; Isotopically Labeled PhIP
EINECS	Contact for details

Quality Control

Every batch of our 2-Amino-1-(trideuteromethyl)-6-phenylimidazo[4,5-b]pyridine is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, verified by advanced spectroscopic and chromatographic techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical data is provided with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.