Description

3-Amino-1,4-Dimethyl-5H-Pyrido[4,3-B]Indole-3-14C, Acetate is a carbon-14 labeled derivative of a complex heterocyclic amine, specifically designed for advanced research and development applications. This compound is of critical importance for metabolic and pharmacokinetic studies, where precise tracking of molecular pathways is required. It is primarily utilized by pharmaceutical and biotechnology R&D teams, as well as specialized contract research organizations (CROs), for use as a radiolabeled tracer in drug discovery and development programs.

Application

• Radiolabeled Tracer in ADME Studies: Used to investigate the Absorption, Distribution, Metabolism, and Excretion of novel pharmaceutical compounds in preclinical research.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for quantifying metabolic pathways, identifying metabolites, and understanding the biological fate of drug candidates.
• Biochemical Pathway Analysis: Enables the tracing of specific molecular structures within complex biological systems to elucidate mechanisms of action.
• Reference Standard for Analytical Method Development: Serves as a critical standard for developing and validating sensitive analytical methods like LC-MS/MS for metabolite detection.
• Environmental Fate Studies: Applied in specialized research to track the environmental breakdown and persistence of chemical compounds.

Basic Information

Product Name	3-Amino-1,4-Dimethyl-5H-Pyrido[4,3-B]Indole-3-14C, Acetate
CAS No.	210049-08-4
Molecular Formula	C₁₅H₁₅N₃O₂ * (¹⁴C labeled)
Molecular Weight	~269.30 g/mol (unlabeled)
Synonyms	3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole-3-14C acetate; Trp-P-2-14C, Acetate; 3-Amino-1-methyl-5H-pyrido[4,3-b]indole-14C acetate (common naming variant); 1,4-Dimethyl-3-amino-5H-pyrido[4,3-b]indole-3-14C acetate; [3-14C]-Trp-P-2 acetate; Radiolabeled Trp-P-2 acetate; Heterocyclic aromatic amine-14C tracer; 14C-labeled HAA standard.
EINECS	Contact for details

Quality Control

Every batch of this specialized radiolabeled compound is produced and analyzed under strict cGMP-like conditions to ensure identity, purity, and specific activity. Quality is verified via orthogonal analytical techniques including HPLC with radiometric detection, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing chemical and radiochemical purity, specific activity (mCi/mmol or GBq/mmol), and solvent composition. Our quality systems are designed to meet the stringent requirements of FDA 21 CFR Part 211 for investigational products.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at or below -20°C. The product is hygroscopic (moisture-sensitive) and should be kept under an inert atmosphere after opening. Store in accordance with all local and national regulations for radioactive materials.

Specification

Item	Specification
Appearance	Solid (Color to be specified per batch)
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98% (Chemical)
Radiochemical Purity	≥ 97%
Specific Activity	50-60 mCi/mmol (1.85-2.22 GBq/mmol) [Custom ranges available]
Solvent (if supplied as solution)	Specified on COA (e.g., Ethanol, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.