Description

2-(2,4-Difluorophenyl)Thiophene is a high-purity fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of active pharmaceutical ingredients (APIs) and functional materials, where its unique difluorophenyl-thiophene scaffold imparts desirable electronic and physicochemical properties. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and material science industries seeking to innovate new molecular entities.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, particularly in kinase inhibitor and CNS-active therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and fungicides, leveraging the bioactivity of the fluorinated aromatic system.
• Material Science Precursor: Serves as a building block for organic semiconductors, OLED (Organic Light-Emitting Diode) materials, and conductive polymers.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for transition metal catalysis and asymmetric synthesis.
• Chemical Research: A versatile substrate for cross-coupling reactions (e.g., Suzuki, Stille) and other functionalization studies in academic and industrial laboratories.
• Fluorine Chemistry Studies: Used as a model compound for investigating the effects of fluorine substitution on molecular conformation and reactivity.

Basic Information

Product Name	2-(2,4-Difluorophenyl)Thiophene
CAS No.	209592-66-5
Molecular Formula	C10H6F2S
Molecular Weight	196.22 g/mol
Synonyms	2-(2,4-Difluorophenyl)thiophene; Thiophene, 2-(2,4-difluorophenyl)-; 2,4-Difluorophenylthiophene; 2-(2,4-Difluorophenyl)-thiophene; 2-(2,4-Difluorophenyl)thiophene; 209592-66-5; 2-(2,4-Difluorophenyl)thiophene (CAS 209592-66-5)
EINECS	Contact for details

Quality Control

Our 2-(2,4-Difluorophenyl)Thiophene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, supporting our clients' needs in regulated development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.