Description

tert-Butyl 2-(6-Bromo-1H-Indol-3-Yl)Ethylcarbamate is a high-purity, advanced pharmaceutical intermediate featuring a brominated indole core protected by a Boc (tert-butoxycarbonyl) group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of complex bioactive molecules. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) engaged in the discovery of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to develop new chemical entities.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component for constructing heterobifunctional molecules designed for targeted protein degradation.
• Kinase Inhibitor Synthesis: Employed in the construction of indole-based scaffolds for potential kinase inhibitors.
• Peptidomimetic Chemistry: The protected amine functionality makes it suitable for incorporation into peptide-like structures to enhance metabolic stability.
• Chemical Biology Probes: Used to create labeled or tagged molecules for studying biological processes and target engagement.

Basic Information

Item	Details
Product Name	tert-Butyl 2-(6-Bromo-1H-Indol-3-Yl)Ethylcarbamate
CAS No.	209168-88-7
Molecular Formula	C₁₅H₁₉BrN₂O₂
Molecular Weight	339.23 g/mol
Synonyms	Boc-6-Bromotryptamine; 2-(6-Bromo-1H-indol-3-yl)ethylcarbamic acid tert-butyl ester; N-Boc-6-Bromotryptamine; 6-Bromo-N-Boc-tryptamine; tert-Butyl (2-(6-bromo-1H-indol-3-yl)ethyl)carbamate; 6-Bromotryptamine Boc derivative; 209168-88-7; Boc-6-Br-Trp-OH
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 2-(6-Bromo-1H-Indol-3-Yl)Ethylcarbamate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research and development specifications. Our quality commitment supports applications requiring high standards of chemical integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.