Description

Methyl 3-Amino-5-(4-Isobutylphenyl)Thiophene-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound is a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for non-steroidal anti-inflammatory drugs (NSAIDs) and other therapeutic agents. It is essential for research and development chemists, process scale-up engineers, and manufacturers in the global pharmaceutical and fine chemical industries seeking reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel NSAID candidates and other proprietary drug molecules.
• Active Pharmaceutical Ingredient (API) Synthesis: Used as a core scaffold for constructing complex heterocyclic structures in API manufacturing.
• Research & Development: Serves as a valuable building block in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Employed in route scouting and scale-up processes for the efficient production of target compounds.
• Fine Chemical Production: Utilized in the manufacture of specialized, high-value chemicals for various industrial applications.

Basic Information

Product Name	Methyl 3-Amino-5-(4-Isobutylphenyl)Thiophene-2-Carboxylate
CAS No.	208944-55-2
Molecular Formula	C16H19NO2S
Molecular Weight	289.39 g/mol
Synonyms	Methyl 3-amino-5-(4-isobutylphenyl)thiophene-2-carboxylate; 3-Amino-5-(4-isobutylphenyl)thiophene-2-carboxylic acid methyl ester; 2-Thiophenecarboxylic acid, 3-amino-5-[4-(2-methylpropyl)phenyl]-, methyl ester; Methyl 3-amino-5-(p-isobutylphenyl)thiophene-2-carboxylate; 208944-55-2; 5-(4-Isobutylphenyl)-3-aminothiophene-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 3-Amino-5-(4-Isobutylphenyl)Thiophene-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical development and manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.