Description

Bicyclo[2.2.1]Heptane-2,7-Dicarboxylic Acid, 7-Amino-, (1S,2S,4R,7S)- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its rigid, polycyclic norbornane skeleton and multiple functional groups make it a valuable precursor for constructing complex molecular architectures with precise three-dimensional control. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, asymmetric catalysis, and the development of novel materials.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders or requiring specific stereochemistry for efficacy.
• Ligand and Catalyst Development: Utilized in the design and synthesis of novel chiral ligands and organocatalysts for asymmetric synthesis, enhancing enantioselectivity in critical bond-forming reactions.
• Advanced Material Precursor: Acts as a monomer or cross-linking agent in the development of specialty polymers, resins, and dendrimers with unique thermal and mechanical properties.
• Agrochemical Research: Employed in the discovery and optimization of new herbicides, fungicides, and plant growth regulators that leverage its constrained geometry.
• Peptidomimetics and Bioisosteres: Its structure is valuable for creating conformationally restricted peptide analogs and bioisosteres in drug design to improve metabolic stability and receptor binding affinity.
• Chemical Biology Probes: Used to develop molecular probes and tools for studying enzyme mechanisms and protein-ligand interactions.

Basic Information

Product Name	Bicyclo[2.2.1]Heptane-2,7-Dicarboxylic Acid, 7-Amino-, (1S,2S,4R,7S)- (9Ci)
CAS No.	208838-02-2
Molecular Formula	C10H13NO4
Molecular Weight	211.21 g/mol
Synonyms	(1S,2S,4R,7S)-7-Aminobicyclo[2.2.1]heptane-2,7-dicarboxylic acid; (1S,2S,4R,7S)-7-Amino-2,7-norbornanedicarboxylic acid; 7-Amino-2,7-norbornanedicarboxylic acid, (1S,2S,4R,7S)-; endo-7-Aminobicyclo[2.2.1]heptane-2-endo,7-dicarboxylic acid; Chiral Norbornane Amino Diacid; 208838-02-2; (1S,2S,4R,7S)-7-Azanyl-2,7-bicyclo[2.2.1]heptanedicarboxylic acid
EINECS	Contact for details

Quality Control

Every batch of Bicyclo[2.2.1]Heptane-2,7-Dicarboxylic Acid, 7-Amino-, (1S,2S,4R,7S)- (9Ci) is manufactured and analyzed under strict quality management protocols to ensure high purity, consistent stereochemical integrity, and batch-to-batch reproducibility. Our products undergo rigorous quality testing, including chiral HPLC analysis, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.