Description

3-Azabicyclo[3.1.0]Hexane-3-Carboxylicacid,6-Amino-,1,1-Dimethylethylester CAS NO 208837-83-6 is a high-value, bicyclic amino acid ester derivative that serves as a critical chiral building block in advanced organic synthesis. Its unique constrained scaffold and functional groups make it an essential intermediate for constructing complex molecular architectures with high stereochemical fidelity. This compound is primarily sought after by pharmaceutical R&D and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring rigid, three-dimensional pharmacophores.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates, including protease inhibitors, neurological agents, and antiviral compounds.
• Peptidomimetics & Constrained Peptide Synthesis: Used to introduce conformational rigidity into peptide backbones, enhancing metabolic stability and receptor selectivity.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology & Proteomics: Employed as a building block for activity-based probes and molecular tools to study enzyme function.
• Agrochemical Research: Utilized in the synthesis of novel, biologically active compounds for crop protection.
• Academic & Industrial R&D: A valuable reagent for methodological development in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	3-Azabicyclo[3.1.0]Hexane-3-Carboxylicacid,6-Amino-,1,1-Dimethylethylester
CAS No.	208837-83-6
Molecular Formula	C11H18N2O2
Molecular Weight	210.27 g/mol
Synonyms	tert-Butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate; (1S,5R,6R)-6-Amino-3-azabicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester; 3-N-Boc-6-amino-3-azabicyclo[3.1.0]hexane; 3-Azabicyclo[3.1.0]hexane-3-carboxylic acid, 6-amino-, 1,1-dimethylethyl ester; 6-Amino-3-azabicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester; Bicyclic Proline Derivative; tert-Butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate hydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our 3-Azabicyclo[3.1.0]Hexane-3-Carboxylicacid,6-Amino-,1,1-Dimethylethylester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and cGMP intermediate applications. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral content, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.