Description

Ethyl 5-[(3R)-4-Amino-3-Hydroxybutyl]Thiophene-2-Carboxylate is a high-purity chiral intermediate featuring a thiophene core with amino and hydroxyl functional groups. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), where its defined stereochemistry ensures the efficacy and safety of the final drug product. It is primarily required by pharmaceutical R&D and manufacturing sectors for the development of novel therapeutics, including enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, particularly in oncology and metabolic disease research.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex, stereochemically pure APIs requiring a thiophene-based scaffold.
• Biochemical Research: Serves as a precursor for designing and testing enzyme inhibitors or receptor ligands in medicinal chemistry programs.
• Process Development & Scale-Up: Employed in process chemistry for optimizing synthetic routes from laboratory to pilot and commercial scale production.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and CDMO (Contract Development and Manufacturing Organization) services.

Basic Information

Product Name	Ethyl 5-[(3R)-4-Amino-3-Hydroxybutyl]Thiophene-2-Carboxylate
CAS No.	208337-84-2
Molecular Formula	C11H17NO3S
Molecular Weight	243.32 g/mol
Synonyms	Ethyl 5-[(3R)-4-Amino-3-hydroxybutyl]-2-thiophenecarboxylate; (R)-Ethyl 5-(4-amino-3-hydroxybutyl)thiophene-2-carboxylate; 2-Thiophenecarboxylic acid, 5-[(3R)-4-amino-3-hydroxybutyl]-, ethyl ester; 208337-84-2; UNII-9F8J0F8K2A; 9F8J0F8K2A; AKOS025310999; SCHEMBL15450497; DB14960
EINECS	Contact for details

Quality Control

Our Ethyl 5-[(3R)-4-Amino-3-Hydroxybutyl]Thiophene-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere or inert gas to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (3R)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.