Description

Ethyl 5-[(3R)-3,4-Dihydroxybutyl]Thiophene-2-Carboxylate is a high-purity chiral intermediate featuring a thiophene core with a functionalized butyl side chain. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs) and advanced organic materials. It is primarily sought by research and development teams, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel molecules with specific stereochemical requirements.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and production of novel therapeutic agents, particularly in cardiovascular and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the thiophene moiety and chiral dihydroxybutyl chain contribute to biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials due to the conjugated thiophene system.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes under cGMP conditions.
• Academic & Industrial R&D: Utilized in exploratory chemistry for studying structure-activity relationships (SAR) and developing new synthetic methodologies.

Basic Information

Product Name	Ethyl 5-[(3R)-3,4-Dihydroxybutyl]Thiophene-2-Carboxylate
CAS No.	208337-83-1
Molecular Formula	C11H16O4S
Molecular Weight	244.31 g/mol
Synonyms	Ethyl 5-[(3R)-3,4-dihydroxybutyl]-2-thiophenecarboxylate; (R)-Ethyl 5-(3,4-dihydroxybutyl)thiophene-2-carboxylate; 2-Thiophenecarboxylic acid, 5-[(3R)-3,4-dihydroxybutyl]-, ethyl ester; UNII-9F8R6H8U7I; 9F8R6H8U7I; SCHEMBL218062; AKOS040759626; A1-01626
EINECS	Contact for details

Quality Control

Our Ethyl 5-[(3R)-3,4-Dihydroxybutyl]Thiophene-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.