Description

Tris(Hydroxy-D-Methyl)Amino-D2-Methane, 98 Atom % D is a high-purity, deuterated derivative of the common biological buffer agent, tris(hydroxymethyl)aminomethane (Tris). This compound matters for its role as a critical reagent in advanced spectroscopic and analytical techniques, where its deuterium labeling minimizes background interference. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and chemical synthesis sectors for applications in Nuclear Magnetic Resonance (NMR) spectroscopy, mass spectrometry, and the development of deuterated active pharmaceutical ingredients (APIs).

Application

• Internal standard and reference compound in deuterium NMR spectroscopy for structural elucidation.
• Building block for the synthesis of deuterium-labeled pharmaceutical compounds and biochemical probes.
• Use in mass spectrometry as a matrix or calibrant for accurate mass measurement.
• Preparation of deuterated buffer solutions for specialized biochemical and biophysical studies.
• Intermediate in organic synthesis requiring isotopically labeled reagents.
• Research tool in metabolic pathway tracing and mechanistic studies.

Basic Information

Product Name	Tris(Hydroxy-D-Methyl)Amino-D2-Methane, 98 Atom % D
CAS No.	207802-44-6
Molecular Formula	C4D11NO3
Molecular Weight	128.19 g/mol (deuterated form)
Synonyms	Tris-d11; Deuterated Tris Buffer; Tris(trideuteriomethyl-d3)amine-d2; 2-Amino-2-(hydroxymethyl)-1,3-propanediol-d11; TRIS-d11; (HO-CD3)3C-ND2; Trometamol-d11; Tris(hydroxymethyl-d3)aminomethane-d2
EINECS	Contact for details

Quality Control

Our Tris(Hydroxy-D-Methyl)Amino-D2-Methane is produced under controlled conditions to ensure high isotopic and chemical purity. Each batch undergoes rigorous quality testing, including NMR and mass spectrometry, to confirm the deuterium atom percent enrichment and chemical identity. Certificates of Analysis (COA) detailing the specific analytical results are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed in a desiccated environment to prevent moisture absorption, which can affect purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Deuterium Enrichment (NMR)	≥ 98 Atom % D
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.