Description

Dipyrrolidino(n-Succinimidyloxy)Carbenium Hexafluorophosphate is a highly reactive, crystalline organic salt primarily used as a peptide coupling reagent. This compound matters for its efficiency in facilitating amide bond formation, a critical reaction in pharmaceutical synthesis and peptide research. It is specifically needed by research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for synthesizing complex peptides and other sensitive organic molecules.

Application

• Peptide Synthesis: As a high-efficiency coupling agent for solid-phase and solution-phase peptide synthesis, particularly for sterically hindered or sensitive amino acids.
• Pharmaceutical Intermediates: In the synthesis of active pharmaceutical ingredients (APIs) requiring the formation of challenging amide bonds under mild conditions.
• Bioconjugation: For linking peptides, proteins, or other biomolecules to labels, polymers, or solid supports via amine-reactive chemistry.
• Organic Synthesis Research: As a specialized reagent in academic and industrial R&D for constructing complex amides, esters, and other derivatives.
• Process Chemistry: Used in scale-up and optimization of synthetic routes where high yield and minimal racemization are critical.
• Library Synthesis: For the rapid generation of compound libraries in drug discovery programs through efficient amide coupling.

Basic Information

Product Name	Dipyrrolidino(n-Succinimidyloxy)Carbenium Hexafluorophosphate
CAS No.	207683-26-9
Molecular Formula	C13H20F6N3O2P
Molecular Weight	419.28 g/mol
Synonyms	HSPyU; 1-[(1H-Pyrrolo[2,3-b]pyridin-3-yl)methyl]-3-(2,4,6-trimethylphenyl)urea; PyU; Dipyrrolidino(n-Succinimidyloxy)Carbenium PF6; N-Hydroxysuccinimide ester of dipyrrolidinocarbenium hexafluorophosphate; HONSu ester of PyU; Peptide Coupling Reagent PyU; (Succinimidyloxy)dipyrrolidinocarbenium hexafluorophosphate
EINECS	Contact for details

Quality Control

Our Dipyrrolidino(n-Succinimidyloxy)Carbenium Hexafluorophosphate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and process applications. Each lot is analyzed to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and light-sensitive. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) in a desiccator to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.