Description

N-(Carboxymethyl)-N-[2-(2,5-Dihydro-2,5-Dioxo-1H-Pyrrol-1-Yl) Ethyl] Glycine is a high-purity, functionalized amino acid derivative featuring a reactive maleimide moiety. This compound matters as a versatile heterobifunctional crosslinking agent, enabling the stable conjugation of biomolecules under mild conditions. It is primarily needed by researchers and manufacturers in the bioconjugation, pharmaceutical development, and diagnostic reagent sectors for creating antibody-drug conjugates (ADCs), protein labeling, and advanced polymer synthesis.

Application

• Bioconjugation & ADC Development: As a key linker for covalently attaching cytotoxic drugs, peptides, or fluorescent dyes to antibodies, proteins, or other targeting molecules via its maleimide group's thiol-specific reactivity.
• Protein & Peptide Modification: For site-specific labeling of cysteine residues in proteins for analytical studies, imaging, or therapeutic enhancement.
• Diagnostic Reagent Synthesis: In the production of enzyme-linked immunosorbent assay (ELISA) kits, lateral flow assays, and other diagnostic tools requiring stable antibody-enzyme conjugates.
• Polymer & Material Science: Serving as a functional monomer or crosslinker for synthesizing smart hydrogels, surface coatings, and drug delivery systems with tailored properties.
• Research & Development: A critical tool in academic and industrial R&D for exploring novel drug delivery mechanisms, biomaterial interfaces, and chemical biology.

Basic Information

Product Name	N-(Carboxymethyl)-N-[2-(2,5-Dihydro-2,5-Dioxo-1H-Pyrrol-1-Yl) Ethyl] Glycine
CAS No.	207612-93-9
Molecular Formula	C11H14N2O7
Molecular Weight	286.24 g/mol
Synonyms	Maleimidopropionic acid hydrazide (MPH) derivative; N-(2-Maleimidoethyl)iminodiacetic acid; N-(Carboxymethyl)-N'-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)glycine; Maleimide-PEG2-acid analog; Heterobifunctional Maleimide-NTA linker precursor; 1-[2-[[Carboxymethyl](carboxymethyl)amino]ethyl]-1H-pyrrole-2,5-dione; Iminodiacetic acid, N-(2-maleimidoethyl)-
EINECS	Contact for details

Quality Control

Our N-(Carboxymethyl)-N-[2-(2,5-Dihydro-2,5-Dioxo-1H-Pyrrol-1-Yl) Ethyl] Glycine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.