Description

n-(Carboxymethyl)-n-[2-(2,5-Dihydro-2,5-Dioxo-1H-Pyrrol-1-Yl)Ethyl]- Glycine is a specialized functionalized amino acid derivative featuring a maleimide moiety, making it a valuable intermediate for bioconjugation and polymer chemistry. Its core value lies in its ability to undergo selective Michael addition reactions with thiol groups, enabling the stable and efficient cross-linking of biomolecules and synthetic polymers. This compound is essential for researchers and manufacturers in the pharmaceutical, diagnostic, and advanced materials sectors who require precise and reliable conjugation chemistry for developing targeted therapeutics, biosensors, and functional polymers.

Application

• Bioconjugation Reagent: Used for the site-specific labeling of proteins, antibodies, and peptides via thiol-maleimide chemistry for drug development and diagnostics.
• Linker for ADC (Antibody-Drug Conjugate) Synthesis: Serves as a critical bifunctional linker to connect cytotoxic payloads to monoclonal antibodies.
• Polymer Functionalization: Enables the introduction of carboxylic acid and maleimide groups onto polymer backbones for creating smart, responsive materials and hydrogels.
• Surface Modification: Used to functionalize gold nanoparticles, quantum dots, and other surfaces with maleimide groups for biosensor and assay development.
• Cross-linking Agent: Facilitates the formation of stable cross-links in protein or polymer networks for tissue engineering and biomaterial fabrication.
• Intermediate for Specialty Chemicals: A key building block in the synthesis of more complex heterobifunctional cross-linkers and pharmaceutical intermediates.

Basic Information

Product Name	n-(Carboxymethyl)-n-[2-(2,5-Dihydro-2,5-Dioxo-1H-Pyrrol-1-Yl)Ethyl]- Glycine
CAS No.	207612-92-8
Molecular Formula	C9H10N2O6
Molecular Weight	242.19 g/mol
Synonyms	N-(Carboxymethyl)-N-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethyl]glycine; Maleimidopropionic Acid-EDTA; N-(2-Maleimidoethyl)iminodiacetic Acid; Maleimide-EDTA; 1-[2-(Carboxymethyl)(carboxymethyl)aminoethyl]-1H-pyrrole-2,5-dione; Maleimide-C2-IDA; N-(2-Maleimidoethyl)IDA; Glycine, N-(carboxymethyl)-N-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethyl]-
EINECS	Contact for details

Quality Control

Our n-(Carboxymethyl)-n-[2-(2,5-Dihydro-2,5-Dioxo-1H-Pyrrol-1-Yl)Ethyl]- Glycine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. Due to its hygroscopic nature, the container should be kept tightly sealed in a desiccated environment to prevent moisture absorption, which can affect reactivity and purity. Allow the sealed container to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.