Description

5-Amino-2-Aza-Bicyclo[2.2.1]Heptane-2-Carboxylic Acid tert-Butyl Ester is a high-purity, protected amino acid derivative featuring a rigid bicyclic scaffold. This compound is a critical chiral building block for the synthesis of complex pharmaceutical molecules, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly in areas like protease inhibitors and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, especially for targeting proteases and other enzymes.
• Peptidomimetics Synthesis: Used to construct constrained peptide analogs that mimic natural peptides but with enhanced metabolic stability and bioavailability.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in stereoselective chemical transformations to introduce complex molecular architectures.
• Bioconjugation & Probe Development: The protected amino group allows for selective deprotection and further functionalization, useful in creating biochemical probes.

Basic Information

Product Name	5-Amino-2-Aza-Bicyclo[2.2.1]Heptane-2-Carboxylic Acid tert-Butyl Ester
CAS No.	207405-62-7
Molecular Formula	C11H20N2O2
Molecular Weight	212.29 g/mol
Synonyms	tert-Butyl 5-amino-2-azabicyclo[2.2.1]heptane-2-carboxylate; 2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 5-amino-, 1,1-dimethylethyl ester; 5-Amino-2-aza-norbornane-2-carboxylic acid tert-butyl ester; (1R,4S)-5-Amino-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester (for specific enantiomer); 2-N-Boc-5-amino-2-azabicyclo[2.2.1]heptane; AABH-OtBu; Protected 2-Azabicyclo[2.2.1]heptane-5-amine-2-carboxylate
EINECS	Contact for details

Quality Control

Our 5-Amino-2-Aza-Bicyclo[2.2.1]Heptane-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure high chemical purity and chiral integrity, suitable for demanding research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess (where applicable), and impurity profiles. We adhere to cGMP principles where required, and specifications can be tailored to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e. (for enantiopure grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.