Description

Irampanel is a high-purity, non-competitive AMPA receptor antagonist with significant pharmacological activity. This compound is of critical importance for research and development in the field of neuroscience and central nervous system (CNS) disorders. It serves as a valuable reference standard and active pharmaceutical ingredient (API) for scientists and manufacturers focused on neurological therapeutics, particularly for conditions involving glutamate excitotoxicity.

Application

• Neurological Research: Primary tool compound for studying the role of AMPA receptors in synaptic plasticity, learning, memory, and neurodegenerative processes.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development, validation, and quality control of related pharmaceutical products.
• Pharmaceutical Development: Serves as a key intermediate or active ingredient in the preclinical and clinical development of novel neuroprotective agents and treatments for stroke, epilepsy, and traumatic brain injury.
• Mechanistic Studies: Employed in vitro and in vivo to investigate pathways of glutamate-mediated excitotoxicity and to evaluate potential therapeutic interventions.

Basic Information

Product Name	Irampanel
CAS No.	206260-33-5
Molecular Formula	C15H13N3O4S
Molecular Weight	331.35 g/mol
Synonyms	ZK 200775; (R)-4-Acetyl-6,8-difluoro-1,4-dihydro-2,3-quinoxalinedione; 4-Acetyl-6,8-difluoro-1,4-dihydro-2,3-quinoxalinedione; AMPA Receptor Antagonist ZK200775; Irampanel (ZK200775); ZK-200775; ZK 200775N
EINECS	Contact for details

Quality Control

Our Irampanel is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤0.5%
Assay (HPLC)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.