Description

2,2,6,6-Tetramethylpiperidine-D18-1-Oxyl is a perdeuterated, stable nitroxide radical derivative of TEMPO. This compound is a crucial spin label and probe in electron paramagnetic resonance (EPR) spectroscopy and dynamic nuclear polarization (DNP) NMR studies. Its deuterated structure minimizes line broadening, making it essential for researchers and manufacturers in advanced materials science, structural biology, and pharmaceutical development who require high-resolution molecular dynamics data.

Application

• EPR/ESR Spectroscopy: As a stable radical probe for studying molecular motion, polymer dynamics, and membrane fluidity.
• Dynamic Nuclear Polarization (DNP): Used as a polarizing agent to dramatically enhance sensitivity in solid-state and solution NMR spectroscopy.
• Spin Labeling: For site-directed spin labeling (SDSL) of proteins, nucleic acids, and other biomolecules to investigate structure and conformational changes.
• Polymer Chemistry: Acts as a mediator in controlled/living radical polymerization (e.g., nitroxide-mediated polymerization, NMP).
• Oxidation Catalyst: Serves as a catalyst or co-catalyst in selective oxidation reactions of alcohols and other organic substrates.
• Antioxidant Research: Used as a model compound to study radical scavenging activity and oxidative stress mechanisms.
• Materials Science: Incorporated into organic semiconductors, liquid crystals, and magnetic materials to study and tune electronic properties.

Basic Information

Product Name	2,2,6,6-Tetramethylpiperidine-D18-1-Oxyl
CAS No.	205679-68-1
Molecular Formula	C9D18NO
Molecular Weight	186.38 g/mol
Synonyms	Perdeuterated TEMPO; TEMPO-d18; 2,2,6,6-Tetramethyl-1-oxyl-4-piperidinol-d18; 4-Hydroxy-TEMPO-d18; 4-Oxo-TEMPO-d18; (2,2,6,6-Tetramethylpiperidin-1-yl)oxyl-d18; 1-Oxyl-2,2,6,6-tetramethyl-4-piperidinol-d18; Stable Nitroxyl Radical-d18
EINECS	Contact for details

Quality Control

Our 2,2,6,6-Tetramethylpiperidine-D18-1-Oxyl is manufactured under strict quality control protocols to ensure high isotopic purity and chemical stability. Each batch is characterized by NMR, EPR, and mass spectrometry to confirm deuteration level and radical purity. Certificates of Analysis (COA) detailing specific analytical results are provided with every shipment to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) in a cool, dry, well-ventilated place. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Orange to red crystalline solid or powder
Identification (IR)	Conforms to structure
Deuteration Degree (D-content)	≥ 98 atom % D
Assay (EPR / Titration)	≥ 97.0%
Purity (HPLC)	≥ 98.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.