Description

Phenyl-2-Aminopropane-1,1,2,3,3,3-D6 Hcl is a deuterated isotopologue of amphetamine, where six hydrogen atoms are replaced with deuterium, a stable, non-radioactive isotope. This high-purity labeled compound is critical for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical workflows. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, forensic toxicology, and clinical diagnostics sectors who require definitive compound identification and precise quantification.

Application

• Internal Standard for LC-MS/MS: Primary application as a deuterated internal standard for the accurate quantification of amphetamine and related compounds in complex biological matrices like plasma, urine, and hair.
• Forensic Analysis & Toxicology: Used in method development and routine testing for drug-of-abuse screening, workplace testing, and post-mortem investigations to ensure legally defensible results.
• Pharmacokinetic & Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Pharmaceutical Quality Control: Supports impurity profiling and assay validation for amphetamine-based active pharmaceutical ingredients (APIs) and finished dosage forms.
• Reference Material for Certified Standards: Serves as a high-purity building block for certified reference material (CRM) manufacturers.
• Isotope Dilution Mass Spectrometry (IDMS): Fundamental component in IDMS, the gold-standard technique for achieving the highest possible analytical accuracy.

Basic Information

Product Name	Phenyl-2-Aminopropane-1,1,2,3,3,3-D6 Hcl
CAS No.	205437-60-1
Molecular Formula	C9H7D6ClN
Molecular Weight	187.72 g/mol
Synonyms	(±)-Amphetamine-d6 hydrochloride; 1-Phenyl-2-aminopropane-d6 HCl; α-Methylbenzeneethanamine-d6 hydrochloride; Benzenethanamine, α-methyl-d6, hydrochloride; DL-Amphetamine-d6 HCl; Deuterated Amphetamine HCl; Amphetamine D6 Internal Standard; 2-Amino-1-phenylpropane-d6 hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Phenyl-2-Aminopropane-1,1,2,3,3,3-D6 Hcl is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity to meet the exacting demands of analytical reference standards. Certificates of Analysis (COA) are provided with each shipment, detailing results from NMR (¹H, ¹³C), mass spectrometry, HPLC, and residual solvent analysis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed immediately after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.