Description

2-Oxo-1,2-Dihydro-Spiro[Indole-3,3'-Pyrrolidine]-1'-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic indole-pyrrolidine scaffold. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly in oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex small-molecule drug candidates, especially those targeting protein-protein interactions.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing spirocyclic compound libraries for high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• Oncology Drug Development: Used in the research and development of potential kinase inhibitors and other targeted cancer therapies.
• CNS Drug Discovery: Employed in the synthesis of novel compounds being investigated for neurological and psychiatric conditions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for studies in synthetic organic chemistry and new synthetic methodology development.

Basic Information

Product Name	2-Oxo-1,2-Dihydro-Spiro[Indole-3,3'-Pyrrolidine]-1'-Carboxylic Acid tert-Butyl Ester
CAS No.	205383-87-5
Molecular Formula	C17H20N2O3
Molecular Weight	300.36 g/mol
Synonyms	1'-tert-Butyl 2-Oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-1'-carboxylate; tert-Butyl 2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-1'-carboxylate; Spiro[indole-3,3'-pyrrolidine]-1'-carboxylic acid, 1,2-dihydro-2-oxo-, 1,1-dimethylethyl ester; 1,1-Dimethylethyl 1,2-dihydro-2-oxospiro[indole-3,3'-pyrrolidine]-1'-carboxylate; BOC-Spiroindolone; tert-Butyl 2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxylate
EINECS	Contact for details

Quality Control

Our 2-Oxo-1,2-Dihydro-Spiro[Indole-3,3'-Pyrrolidine]-1'-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.