Description

(R)-n-Acetyl-5-Bromo-3-(n-Methylpyrrolidin-2-Ylmethyl)-1H-Indole is a high-purity chiral indole derivative, a critical advanced intermediate in modern pharmaceutical synthesis. Its value lies in its complex, functionalized structure which serves as a key building block for the development of novel, targeted therapeutic agents. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and process development of new drugs, particularly in the areas of central nervous system (CNS) and oncology research.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral scaffold in the synthesis of novel drug candidates, particularly for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop compounds with improved efficacy and selectivity.
• Process Chemistry Development: Employed in scaling up synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Asymmetric Synthesis: Utilized as a chiral building block to introduce stereochemical complexity into target molecules, a key requirement for many modern drugs.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical industry.
• Reference Standard: Can be used as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Product Name	(R)-n-Acetyl-5-Bromo-3-(n-Methylpyrrolidin-2-Ylmethyl)-1H-Indole
CAS No.	205369-12-6
Molecular Formula	C₁₇H₂₁BrN₂O
Molecular Weight	349.27 g/mol
Synonyms	(R)-1-(5-Bromo-3-((1-methylpyrrolidin-2-yl)methyl)-1H-indol-1-yl)ethan-1-one; (R)-N-Acetyl-5-bromo-3-((1-methylpyrrolidin-2-yl)methyl)-1H-indole; 5-Bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole, 1-acetyl-, (2R)-; (R)-5-Bromo-3-((1-methylpyrrolidin-2-yl)methyl)-1-acetylindole; (R)-ABMPI; (R)-Acetyl-5-bromo-3-(N-methylpyrrolidin-2-ylmethyl)indole
EINECS	Contact for details

Quality Control

Our (R)-n-Acetyl-5-Bromo-3-(n-Methylpyrrolidin-2-Ylmethyl)-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity, to meet the exacting standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage, consider storage at 2-8°C under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤3.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.