Description

L-Arginine-Guanido-15N2Hcl is a stable isotope-labeled derivative of the essential amino acid L-arginine, specifically enriched with nitrogen-15 on the guanidino group. This high-purity labeled compound is critical for advanced research and development requiring precise metabolic and pharmacokinetic tracing. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and academic research sectors for applications in mass spectrometry, NMR spectroscopy, and clinical diagnostics.

Application

• Biomedical Research & Drug Development: Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and LC-MS/MS for the accurate quantification of L-arginine and related metabolites in biological samples.
• Metabolic Pathway Analysis: Serves as a tracer in metabolic flux studies to investigate nitric oxide synthesis, urea cycle dynamics, and other arginine-dependent pathways.
• Proteomics & Stable Isotope Labeling by Amino acids in Cell culture (SILAC): Enables quantitative mass spectrometry-based proteomics for studying protein expression, turnover, and post-translational modifications.
• Clinical Diagnostics: Employed in the development and calibration of diagnostic assays for monitoring conditions related to arginine metabolism, such as cardiovascular and renal diseases.
• Nutritional Science Research: Acts as a tracer to study protein metabolism, amino acid absorption, and the effects of dietary supplements in vivo.
• Pharmaceutical Impurity Profiling: Utilized as a reference standard to identify and quantify impurities or degradants in pharmaceutical formulations containing arginine.

Basic Information

Product Name	L-Arginine-Guanido-15N2Hcl
CAS No.	204633-92-1
Molecular Formula	C6H15ClN4O2
Molecular Weight	210.66 g/mol (for unlabeled form; exact mass varies with isotope enrichment)
Synonyms	L-Arginine-guanidino-15N2 hydrochloride; (S)-2-Amino-5-((15N)amino(15N)methylidene)aminopentanoic acid hydrochloride; Arg-guanidino-15N2 HCl; L-[guanidino-15N2]Arginine hydrochloride; Isotope-labeled L-Arginine HCl; Stable Isotope-Labeled Amino Acid; 15N2-L-Arginine(guanidino) hydrochloride
EINECS	Contact for details

Quality Control

Our L-Arginine-Guanido-15N2Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for chemical purity, NMR and MS for isotopic enrichment verification, and tests for residual solvents and heavy metals. Certificates of Analysis (COA) detailing batch-specific results for identity, purity, isotopic abundance, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure and isotopic labeling pattern
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % 15N (guanidino-15N2)
Optical Rotation	[α]20/D: +21.0° to +23.0° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.