Description

Methacrylonitrile (15N) is a stable isotope-labeled derivative of methacrylonitrile, where the nitrogen atom is enriched with the 15N isotope. This compound is essential for advanced research and analytical applications requiring precise molecular tracing and quantification. It is particularly valuable for scientists and manufacturers in the fields of pharmaceutical development, polymer research, and metabolic studies where isotopic labeling is critical for NMR spectroscopy and mass spectrometry.

Application

• NMR Spectroscopy Internal Standard: Used as a quantitative and qualitative reference standard in nuclear magnetic resonance (NMR) analysis.
• Mass Spectrometry Tracer: Serves as a labeled precursor or internal standard in LC-MS and GC-MS for pharmacokinetic and metabolic pathway studies.
• Polymer Research: Acts as a labeled monomer for synthesizing isotopically labeled polymers to study polymerization mechanisms, kinetics, and material properties.
• Pharmaceutical Development: Employed in the synthesis of labeled drug candidates and metabolites for absorption, distribution, metabolism, and excretion (ADME) research.
• Chemical Synthesis Intermediate: Used in organic synthesis to introduce a labeled nitrile or methacrylate functional group into target molecules.
• Environmental & Agricultural Research: Applied as a tracer in studies investigating the environmental fate of nitrile-based compounds.

Basic Information

Product Name	Methacrylonitrile (15N)
CAS No.	204523-22-8
Molecular Formula	C4H515N
Molecular Weight	68.09 g/mol (for 15N isotope)
Synonyms	2-Methyl-2-propenenitrile-15N; 2-Methylacrylonitrile-15N; Isobutenenitrile-15N; MAN-15N; 15N-Methacrylonitrile; (2-15N)-2-Methylprop-2-enenitrile; 2-Cyano-15N-2-propene
EINECS	Contact for details

Quality Control

Our Methacrylonitrile (15N) is produced and handled under strict quality protocols to ensure high isotopic and chemical purity for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and impurity profiles. We adhere to cGMP principles for consistent quality, and specifications can be tailored to meet specific research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place away from heat, sparks, and open flames. Due to its highly volatile and light-sensitive nature, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C for long-term stability. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms to structure
Isotopic Enrichment (15N)	≥ 98 atom %
Assay (GC)	≥ 99.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	≤ 0.5% total

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.