Description

Fmoc-L-1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid is a high-purity, non-proteinogenic amino acid derivative used as a critical building block in solid-phase peptide synthesis (SPPS). This compound matters because it enables the precise incorporation of the constrained 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) scaffold into peptide chains, a modification known to enhance biological activity, stability, and conformational rigidity. It is essential for pharmaceutical R&D teams, peptide manufacturers, and academic researchers developing novel therapeutic peptides, peptidomimetics, and chemical biology probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary use as a protected amino acid derivative for the Fmoc/tBu strategy.
• Pharmaceutical Research: Key intermediate in the development of peptide-based drugs targeting GPCRs, enzymes, and other biological targets.
• Peptidomimetic Design: Incorporation of the rigid Tic backbone to improve metabolic stability and bioavailability of lead compounds.
• Chemical Biology: Synthesis of labeled or modified peptides for structure-activity relationship (SAR) studies and probe development.
• Antimicrobial & Antiviral Peptides: Building block for creating novel peptides with enhanced helical stability and target affinity.
• Neuroscience Research: Synthesis of neuropeptide analogs and ligands for neurological studies.

Basic Information

Product Name	Fmoc-L-1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid
CAS No.	204317-99-7
Molecular Formula	C₂₆H₂₃NO₄
Molecular Weight	413.47 g/mol
Synonyms	Fmoc-Tic-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; Fmoc-L-Tic-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; N-Fmoc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; Fmoc-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; Fmoc-(S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our Fmoc-L-1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive peptide synthesis. Each lot undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.