Description

Acetyl n-(Methyl-D3)-Carnitine is a deuterium-labeled derivative of the essential metabolite L-carnitine, specifically designed for research and analytical applications. This compound is critical for conducting precise metabolic and pharmacokinetic studies, where its stable isotope labeling allows for accurate tracking and quantification without interference from endogenous compounds. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and nutraceutical sectors for applications such as tracer studies, drug metabolism research, and the development of advanced diagnostic assays.

Application

• Isotopic Tracer in Metabolic Research: Used to study fatty acid oxidation, energy metabolism, and mitochondrial function pathways.
• Internal Standard for Quantitative Analysis: Essential for LC-MS/MS and GC-MS methods to ensure accurate quantification of carnitine and its analogs in biological samples.
• Drug Metabolism and Pharmacokinetics (DMPK): Employed in ADME studies to trace the absorption, distribution, metabolism, and excretion of new drug candidates.
• Biomarker Discovery and Validation: Aids in the development and validation of clinical biomarkers related to metabolic disorders.
• Nutritional and Dietary Supplement Research: Used in studies investigating the bioavailability and efficacy of carnitine-based supplements.
• Reference Material for Quality Control: Serves as a high-purity certified reference standard for analytical laboratories.

Basic Information

Product Name	Acetyl n-(Methyl-D3)-Carnitine
CAS No.	204259-54-1
Molecular Formula	C9H15D3NO4
Molecular Weight	207.25 g/mol
Synonyms	Acetyl-D3-carnitine (methyl-D3); (3-Carboxy-2-hydroxypropyl)trimethylammonium-methyl-d3 hydroxide, inner salt, acetate; L-Carnitine inner salt, acetyl-methyl-d3; Acetyl-L-carnitine (methyl-D3); ALCAR-d3; Deuterated Acetylcarnitine; Stable Isotope Labeled Acetylcarnitine
EINECS	Contact for details

Quality Control

Our Acetyl n-(Methyl-D3)-Carnitine is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm identity, isotopic enrichment (typically >98 atom % D), and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.