Description

Sodium Butyrate-3,3,4,4,4-D5 is a stable isotope-labeled derivative of sodium butyrate, where five hydrogen atoms are replaced by deuterium. This compound is essential as a high-purity internal standard and tracer in quantitative mass spectrometry and metabolic research, ensuring analytical accuracy and reliability. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions conducting advanced pharmacokinetic, metabolomic, and stable isotope labeling studies.

Application

• Mass Spectrometry Internal Standard: Used for the precise quantification of butyrate and related metabolites in complex biological matrices via GC-MS or LC-MS.
• Metabolic Pathway Tracing: Employed in stable isotope-resolved metabolomics (SIRM) to elucidate the flux and fate of butyrate in cellular and animal models.
• Pharmacokinetic & Drug Metabolism Studies: Serves as a critical tracer to study the absorption, distribution, metabolism, and excretion (ADME) of butyrate-based therapeutics.
• Microbiome & Gut Health Research: Applied in research investigating short-chain fatty acid (SCFA) production by gut microbiota and its systemic effects.
• Nutritional Science: Used in studies examining the metabolic impact of dietary fibers and prebiotics that influence butyrate levels.
• Reference Material for Assay Development: Provides a certified reference material for developing and validating clinical diagnostic assays targeting SCFAs.

Basic Information

Product Name	Sodium Butyrate-3,3,4,4,4-D5
CAS No.	204244-79-1
Molecular Formula	C4D5H2O2Na or C4H2D5NaO2
Molecular Weight	Approx. 117.12 g/mol
Synonyms	Sodium [3,3,4,4,4-2H5]butyrate; Sodium Butyrate-d5; Butyric-3,3,4,4,4-d5 Acid Sodium Salt; Deuterated Sodium Butyrate; Sodium (2,2,3,3,3-2H5)propionate-1-13C (common misnomer check); [3,3,4,4,4-2H5]Butanoic Acid Sodium Salt; 204244-79-1 (CAS Index Name); Sodium 4,4,4,3,3-d5-butanoate
EINECS	Contact for details

Quality Control

Our Sodium Butyrate-3,3,4,4,4-D5 is manufactured under controlled conditions to ensure exceptional isotopic and chemical purity, critical for research integrity. Each batch is characterized by NMR, HPLC, and mass spectrometry to confirm isotopic enrichment (typically ≥98 atom % D) and chemical assay. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic composition, and residual solvent levels is provided with every shipment to support your compliance and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term stability, consider storing under an inert atmosphere in a desiccator.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to expected mass profile
Purity (HPLC)	≥98.0%
Isotopic Enrichment (NMR/MS)	≥98 atom % D
Chemical Purity (Assay)	≥97.0% (on anhydrous basis)
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.