Description

L-Arginine D7 Hydrochloride is a high-purity, isotopically labeled derivative of the essential amino acid L-Arginine, where seven hydrogen atoms are replaced with deuterium. This compound is a critical tool for advanced analytical research, enabling precise quantification and metabolic pathway tracing in complex biological systems. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and CROs (Contract Research Organizations) engaged in pharmacokinetic studies, proteomics, and biomarker discovery.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a stable, non-interfering reference compound for the accurate quantification of endogenous L-Arginine in biological matrices (e.g., plasma, serum, tissue homogenates) using LC-MS/MS and GC-MS.
• Metabolic Flux Analysis: Used as a tracer to study the urea cycle, nitric oxide synthesis, and polyamine metabolism, providing insights into cellular physiology and disease mechanisms.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for conducting absolute bioavailability studies and assessing the pharmacokinetic profiles of new drug candidates that interact with arginine pathways.
• Proteomics and Biomarker Research: Facilitates the relative and absolute quantification of proteins and peptides in SILAC (Stable Isotope Labeling by Amino acids in Cell culture) and other isotope-coded affinity tag techniques.
• Nutritional and Clinical Research: Enables precise measurement of arginine levels in studies investigating cardiovascular health, immune function, and wound healing.
• Quality Control Reference Material: Acts as a certified reference standard for the calibration of analytical instruments and the validation of methods in GLP/GMP-compliant laboratories.

Basic Information

Product Name	L-Arginine D7 Hydrochloride
CAS No.	204244-77-9
Molecular Formula	C6D7H7N4O2 • HCl
Molecular Weight	~227.7 g/mol
Synonyms	(2S)-2-Amino-5-(diaminomethylideneamino)-2,3,3,4,4,5,5-d7-pentanoic acid hydrochloride; L-Arginine-2,3,3,4,4,5,5-d7 hydrochloride; Arginine-d7 HCl; (S)-2-Amino-5-guanidino-d7-pentanoic acid hydrochloride; Deuterated L-Arginine HCl; L-Arg-d7 HCl; Stable Isotope Labeled L-Arginine Hydrochloride
EINECS	Contact for details

Quality Control

Our L-Arginine D7 Hydrochloride is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for critical research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥98 atom % D), chemical purity (by HPLC), and confirming identity and absence of critical impurities. We adhere to relevant industry standards for high-purity reference materials, ensuring reliability and reproducibility in your analytical workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive). For long-term storage, keep the primary container in a desiccator or under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Deuterium Atom Positions	2,3,3,4,4,5,5-d7
Specific Rotation	+21.0° to +23.0° (c=8 in 6N HCl)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.