Description

2-{[2-(tert-Butoxy)-2-Oxoethyl]Sulfanyl}Acetic Acid is a specialized organic compound featuring a thioether-linked acetic acid moiety protected by a tert-butoxycarbonyl (Boc) group. This molecular architecture makes it a valuable protected intermediate and building block in sophisticated organic synthesis, particularly for the controlled introduction of sulfur-containing carboxylic acid functionalities. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of active pharmaceutical ingredients (APIs), peptide mimetics, and novel materials.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of complex drug molecules, especially those requiring thioether or carboxylic acid groups.
• Peptide Chemistry: Used in the synthesis of modified peptides or peptide conjugates where the sulfur-containing side chain needs to be introduced under mild, orthogonal protection strategies.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands with sulfur and carboxylate donors for metal coordination chemistry and catalysis.
• Material Science Research: Employed in the development of functional polymers or surface modifiers where the Boc-protected acid group allows for controlled polymerization or grafting.
• Chemical Biology Probes: Useful for synthesizing activity-based probes or linkers that target specific enzymatic or biological pathways.
• Agrochemical Synthesis: Acts as an intermediate in the creation of novel herbicides or fungicides with specific sulfur-based modes of action.

Basic Information

Product Name	2-{[2-(tert-Butoxy)-2-Oxoethyl]Sulfanyl}Acetic Acid
CAS No.	204133-20-0
Molecular Formula	C8H14O4S
Molecular Weight	206.26 g/mol
Synonyms	2-[(2-tert-Butoxy-2-oxoethyl)thio]acetic acid; (tert-Butoxycarbonylmethylsulfanyl)acetic acid; Boc-S-CH2-COOH; 2-[(2-((tert-Butoxy)carbonyl)ethyl)sulfanyl]acetic acid; 2-{[2-(tert-Butoxy)-2-oxoethyl]thio}acetic acid; Acetic acid, 2-[[2-[(1,1-dimethylethoxy)carbonyl]ethyl]thio]-; 2-((2-(tert-Butoxy)-2-oxoethyl)thio)acetic acid
EINECS	Contact for details

Quality Control

Our 2-{[2-(tert-Butoxy)-2-Oxoethyl]Sulfanyl}Acetic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as purity, identity, and impurity profiles. Our quality systems are designed to support cGMP-compliant workflows for advanced pharmaceutical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.