Description

(Z)-3-((4,5,6,7-Tetrahydro-1H-Indol-2-Yl)Methylene)Indolin-2-One is a high-purity synthetic organic compound belonging to the indolinone class, serving as a crucial advanced intermediate in pharmaceutical research and development. Its value lies in its role as a specialized building block for constructing complex molecular architectures, particularly in medicinal chemistry programs. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting kinase inhibition and other biological pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with potential therapeutic benefits.
• Chemical Biology Probes: Serves as a core scaffold for developing molecular probes to study enzyme function and cellular signaling mechanisms.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for creating complex heterocyclic compounds with specific stereochemistry.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and impurity profiling.

Basic Information

Product Name	(Z)-3-((4,5,6,7-Tetrahydro-1H-Indol-2-Yl)Methylene)Indolin-2-One
CAS No.	204003-85-0
Molecular Formula	C₁₈H₁₈N₂O
Molecular Weight	278.35 g/mol
Synonyms	(Z)-3-[(4,5,6,7-Tetrahydro-1H-indol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one; 2H-Indol-2-one, 3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1,3-dihydro-, (3Z)-; (Z)-3-((4,5,6,7-Tetrahydro-1H-Indol-2-yl)methylidene)indolin-2-one; 3-((4,5,6,7-Tetrahydro-1H-indol-2-yl)methylene)indolin-2-one (Z-isomer); (Z)-Isomer of 3-(4,5,6,7-Tetrahydroindol-2-ylmethylene)indolin-2-one; SU-11274 (related analog precursor); Indolinone derivative CAS 204003-85-0
EINECS	Contact for details

Quality Control

Our (Z)-3-((4,5,6,7-Tetrahydro-1H-Indol-2-Yl)Methylene)Indolin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.