Description

Butyroyl n-(Methyl-D3)-Carnitine is a stable isotope-labeled analog of butyroyl-L-carnitine, where three hydrogen atoms on the methyl group are replaced by deuterium. This compound is essential for use as an internal standard in quantitative mass spectrometry-based metabolomic studies, ensuring high accuracy and reproducibility in analytical measurements. It is primarily required by pharmaceutical researchers, clinical diagnostic laboratories, and academic institutions focused on lipid metabolism, inborn errors of metabolism, and biomarker discovery.

Application

• Mass Spectrometry Internal Standard: Critical for the precise quantification of endogenous butyroyl-L-carnitine in biological samples (e.g., plasma, urine, tissue) using LC-MS/MS or GC-MS.
• Clinical Diagnostics: Used in assays for screening and monitoring disorders of fatty acid oxidation, such as carnitine/acylcarnitine translocase (CACT) deficiency.
• Metabolomics Research: Enables accurate profiling of acylcarnitine species in studies investigating metabolic pathways, disease mechanisms, and drug effects.
• Pharmaceutical Development: Supports pharmacokinetic and pharmacodynamic studies in drug development programs targeting metabolic diseases.
• Quality Control Reference: Serves as a certified reference material (CRM) for calibrating analytical instruments and validating methods in regulated environments.

Basic Information

Product Name	Butyroyl n-(Methyl-D3)-Carnitine
CAS No.	203805-93-0
Molecular Formula	C12H20D3NO4+ (typically as chloride or other salt)
Molecular Weight	~263.34 g/mol (for free base cation, contact for exact salt form weight)
Synonyms	Butyryl-(methyl-d3)-L-carnitine; (3R)-3-[(Butanoyloxy)(methyl-d3)amino]-4-(trimethylazaniumyl)butanoate; Butanoyl-L-carnitine (methyl-d3); L-Carnitine, butyryl-, (methyl-d3)-; Deuterated Butyroylcarnitine; Butyroylcarnitine-d3; Acylcarnitine C4:0-d3; Internal Standard for C4 Carnitine.
EINECS	Contact for details

Quality Control

Our Butyroyl n-(Methyl-D3)-Carnitine is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure high chemical and isotopic purity, meeting the exacting standards required for research and diagnostic applications. Certificates of Analysis (COA) are provided, detailing specifications such as isotopic enrichment (e.g., D ≥ 98%), chemical purity (by HPLC), and identity confirmation (by NMR and MS).

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (by NMR)	≥ 90%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.