Description

Dl-Glutamic-2,4,4-D3 Acid CAS NO 203805-84-9 is a deuterium-labeled analog of the amino acid glutamic acid, where three hydrogen atoms at the 2,4,4 positions are replaced with deuterium. This stable isotope-labeled compound is essential for advanced analytical research, providing a critical internal standard for precise quantification and metabolic pathway tracing. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for applications in mass spectrometry, NMR spectroscopy, and drug metabolism studies.

Application

• As a stable isotope-labeled internal standard for the accurate quantification of glutamic acid in complex biological matrices using LC-MS/MS and GC-MS.
• In metabolic flux analysis and tracer studies to investigate the glutamine-glutamate pathway in cellular metabolism and neurological research.
• For the synthesis of deuterium-labeled peptides, proteins, or pharmaceutical compounds to study pharmacokinetics and drug metabolism (ADME).
• Use in NMR spectroscopy as a tool to simplify spectra and gain detailed structural and dynamic information about biomolecules.
• In the development and validation of clinical diagnostic assays where precise measurement of glutamate levels is critical.
• As a high-purity reference material in analytical chemistry laboratories for method development and quality control.

Basic Information

Product Name	Dl-Glutamic-2,4,4-D3 Acid
CAS No.	203805-84-9
Molecular Formula	C5H6D3NO4
Molecular Weight	151.14 g/mol
Synonyms	(2,4,4-2H3)-DL-Glutamic Acid; DL-Glutamic-2,4,4-d3 Acid; 2-Aminopentanedioic-2,4,4-d3 Acid; (±)-Glutamic-2,4,4-d3 Acid; Glutamic Acid-d3 (2,4,4); Deuterated DL-Glutamic Acid; DL-Glutamate-d3; 203805-84-9
EINECS	Contact for details

Quality Control

Every batch of Dl-Glutamic-2,4,4-D3 Acid is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing isotopic purity, chemical purity, and specific tests is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Chemical Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.