Description

Dl-Valine-2,3,4,4,4,5,5,5-D8 CAS NO 203784-63-8 is a deuterium-labeled isotopologue of the amino acid DL-valine, where eight hydrogen atoms are replaced with deuterium at specific positions. This high level of isotopic enrichment makes it an essential internal standard for quantitative mass spectrometry, ensuring unparalleled accuracy in analytical measurements. It is primarily utilized by pharmaceutical, biotechnology, and academic research laboratories engaged in metabolomics, pharmacokinetic studies, and protein research.

Application

• Mass Spectrometry Internal Standard: Serves as a critical quantitative reference standard in LC-MS and GC-MS analyses for accurate measurement of endogenous valine levels.
• Metabolomics Research: Used in tracer studies and metabolic flux analysis to investigate biochemical pathways and disease mechanisms.
• Pharmaceutical Development: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion of drug candidates.
• Protein and Peptide Research: Facilitates the study of protein structure, dynamics, and folding through stable isotope labeling techniques.
• Nutritional Science: Applied in research on amino acid metabolism, protein synthesis, and nutritional status assessment.
• Diagnostic Assay Development: Used in the development and validation of clinical diagnostic tests for inborn errors of metabolism.

Basic Information

Item	Detail
Product Name	Dl-Valine-2,3,4,4,4,5,5,5-D8
CAS No.	203784-63-8
Molecular Formula	C5H3D8NO2
Molecular Weight	126.20 g/mol
Synonyms	DL-Valine-d8; (RS)-Valine-d8; (±)-Valine-d8; 2-Amino-3-methylbutanoic-2,3,4,4,4,5,5,5-d8 acid; Valine (D,L)-d8; Deuterated DL-Valine; 2-Azaniumyl-3-methylbutanoate-d8; NSC 760466-d8
EINECS	Contact for details

Quality Control

Our Dl-Valine-2,3,4,4,4,5,5,5-D8 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Each batch is characterized by advanced analytical techniques including NMR and mass spectrometry to confirm deuterium incorporation and chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.