Description

Nortriptyline-D3 Hydrochloride is a deuterium-labeled analog of the tricyclic antidepressant nortriptyline, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity reference material is essential for ensuring accuracy and reliability in pharmacokinetic studies, therapeutic drug monitoring, and forensic toxicology. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities requiring precise and stable isotopic labeling for mass spectrometry applications.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in LC-MS/MS and GC-MS methods for the accurate quantification of nortriptyline in biological matrices such as plasma, serum, and urine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion in clinical and preclinical research.
• Therapeutic Drug Monitoring (TDM): Used to develop and validate assays that monitor nortriptyline concentrations in patient samples to optimize dosage and ensure therapeutic efficacy while minimizing side effects.
• Forensic and Clinical Toxicology: Aids in the confirmatory analysis and quantification of nortriptyline in cases of overdose or post-mortem investigations.
• Drug Metabolism and Disposition Studies: Facilitates research into the metabolic pathways and stability of nortriptyline and related compounds.
• Method Development and Validation: Provides a stable isotopic standard for developing new, highly sensitive, and selective analytical procedures in compliance with regulatory guidelines (e.g., FDA, EMA).

Basic Information

Product Name	Nortriptyline-D3 Hydrochloride
CAS No.	203784-52-5
Molecular Formula	C19H18D3ClN
Molecular Weight	299.86 g/mol
Synonyms	Nortriptyline-d3 HCl; 10,11-Dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-δ5,γ-propylamine-3,3,3-d3 Hydrochloride; 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine-3,3,3-d3 Hydrochloride; 5-(3-Methylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene-3,3,3-d3 Hydrochloride; Nortriptyline (methyl-d3) Hydrochloride; Deuterated Nortriptyline Hydrochloride
EINECS	Contact for details

Quality Control

Our Nortriptyline-D3 Hydrochloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of isotopic purity and chemical identity. Each batch is supplied with a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic enrichment, and impurity profile. We adhere to stringent quality protocols suitable for research and development use in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Content)	≥98 atom % D
Chemical Purity (by HPLC)	≥95.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.