Description

Amitriptyline Hcl (D6) is a deuterated internal standard of the tricyclic antidepressant amitriptyline hydrochloride, specifically designed for analytical and research applications. This high-purity, isotopically labeled compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry and pharmacokinetic studies. It is a critical material for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug metabolism, bioanalytical method development, and forensic toxicology.

Application

• Primary use as an Internal Standard for the precise quantification of amitriptyline and its metabolites in biological matrices (plasma, serum, urine) via LC-MS/MS and GC-MS.
• Critical component in Bioanalytical Method Development and Validation for clinical and preclinical studies of tricyclic antidepressants.
• Essential for Pharmacokinetic (PK) and Drug Metabolism Studies, enabling accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME).
• Used in Forensic and Clinical Toxicology testing to confirm and quantify amitriptyline exposure with high specificity.
• Supports Pharmaceutical Quality Control and stability testing of amitriptyline-based drug products.
• Valuable research tool in Isotope Dilution Mass Spectrometry for achieving superior analytical precision.

Basic Information

Product Name	Amitriptyline Hcl (D6)
CAS No.	203645-63-0
Molecular Formula	C20H17D6ClN • HCl
Molecular Weight	320.32 g/mol (for C20H17D6ClN • HCl)
Synonyms	Amitriptyline-d6 Hydrochloride; 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine-d6 Hydrochloride; 5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene-d6 Hydrochloride; Deuterated Amitriptyline HCl; Amitriptyline (D6) HCl; Amitriptyline Internal Standard (D6); Elavil-d6 Hydrochloride
EINECS	Contact for details

Quality Control

Our Amitriptyline Hcl (D6) is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical standards. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, chemical purity, and isotopic enrichment. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label/COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D6)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.