Description

Boc-Leu-Oh-5,5,5-D3 Monohydrate is a deuterium-labeled derivative of Boc-protected L-leucine, a crucial building block in peptide synthesis. This isotopically labeled compound is essential for advanced research applications requiring precise molecular tracking and analysis. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and analytical service providers specializing in mass spectrometry and metabolic studies.

Application

• Internal Standard in Quantitative Mass Spectrometry (MS): Used for the accurate quantification of peptides, proteins, and metabolites in complex biological matrices.
• Metabolic Pathway Tracing: Employed in pharmacokinetic (PK) and drug metabolism studies to track the fate of leucine-containing drug candidates.
• Stable Isotope Labeling in Peptide Synthesis: Incorporated into custom peptides to create isotopically labeled standards for proteomics research.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Serves as a deuterated probe for structural analysis and dynamics studies of biomolecules.
• Biochemical Research Reagent: Used in enzymatic studies and as a specialized precursor for synthesizing labeled bioactive compounds.

Basic Information

Product Name	Boc-Leu-Oh-5,5,5-D3 Monohydrate
CAS No.	203645-42-5
Molecular Formula	C11H18D3NO5
Molecular Weight	250.30 g/mol (anhydrous basis)
Synonyms	(2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-4,4,4-trideuterio-4-methylpentanoic acid monohydrate; N-(tert-Butoxycarbonyl)-L-leucine-5,5,5-d3 monohydrate; Boc-L-leucine-d3 monohydrate; tert-Butoxycarbonylleucine-d3 monohydrate; N-Boc-L-leucine-5,5,5-d3 hydrate; (S)-2-((tert-Butoxycarbonyl)amino)-4,4,4-trideuterio-4-methylpentanoic acid hydrate
EINECS	Contact for details

Quality Control

Our Boc-Leu-Oh-5,5,5-D3 Monohydrate is manufactured under strict quality systems to ensure high chemical purity and isotopic enrichment. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and specific tests are provided to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Optical Rotation	Contact for details
Water Content (KF)	Theoretical (monohydrate)
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.