Description

Morphine (D9) is a deuterated internal standard of the potent opioid analgesic, morphine, specifically labeled with nine deuterium atoms. This compound is essential for ensuring accuracy and reliability in quantitative analytical methods, particularly in regulated environments. It is primarily used by analytical laboratories and pharmaceutical researchers in the fields of forensic science, clinical toxicology, and drug metabolism and pharmacokinetics (DMPK) studies. Morphine (D9) CAS NO 203578-31-8 provides a critical reference point for precise measurement of morphine and its metabolites.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard in LC-MS/MS and GC-MS methods for the accurate quantification of morphine in biological matrices (e.g., plasma, urine, hair).
• Forensic Toxicology: Critical for confirming and quantifying morphine levels in post-mortem and human performance testing, supporting legal and workplace testing protocols.
• Clinical Research: Used in pharmacokinetic studies to monitor drug concentration-time profiles, bioavailability, and metabolic pathways of morphine in patients.
• Pharmaceutical Development: Supports method development and validation for quality control of morphine-based active pharmaceutical ingredients (APIs) and finished dosage forms.
• Doping Control: Employed in sports anti-doping laboratories to detect and confirm the presence of morphine, a prohibited substance in athletic competitions.
• Metabolite Profiling: Aids in the identification and quantification of morphine metabolites, facilitating a deeper understanding of its biotransformation.

Basic Information

Product Name	Morphine (D9)
CAS No.	203578-31-8
Molecular Formula	C₁₇H₁₀D₉NO₃
Molecular Weight	289.38 g/mol
Synonyms	Morphine-d9; (5α,6α)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol-d9; Deuterated Morphine; Morphine Internal Standard (D9); Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl-, (5α,6α)-, d9; 17-Methylmorphine-d9; Morphine (methyl-d9)
EINECS	Contact for details

Quality Control

Our Morphine (D9) is manufactured and tested to meet the exacting standards required for analytical reference materials. Each batch undergoes rigorous quality testing, including chromatographic purity analysis and isotopic enrichment verification, to ensure consistency and reliability. Certificates of Analysis (COA) are provided, detailing results for assay, isotopic purity, and related substances. We adhere to a quality management system to support applications in GLP/GMP-compliant laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccant or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to expected mass spectrum
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D9)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.