Description

cis-1,2,3,6-Tetrahydrophthalimide (Ring-D6) is a deuterated analog of cis-1,2,3,6-tetrahydrophthalimide, where six hydrogen atoms on the aromatic ring are replaced with deuterium. This compound is a critical stable isotope-labeled intermediate for advanced research and development, particularly in the synthesis of deuterated active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require high-purity, isotopically labeled building blocks for metabolic studies, tracer synthesis, and the development of compounds with enhanced properties.

Application

• Deuterated Pharmaceutical Intermediate: A key building block for synthesizing deuterium-labeled drug candidates, which can offer improved metabolic stability, pharmacokinetic profiles, and patent life extension.
• Agrochemical Research: Used in the development of deuterated pesticides and herbicides to study environmental fate, metabolic pathways, and degradation products.
• Metabolic Tracer Synthesis: Essential for creating internal standards and tracers used in quantitative mass spectrometry (LC-MS/MS, GC-MS) for accurate bioanalysis and drug metabolism studies.
• Material Science Research: Serves as a precursor for deuterated polymers or organic electronic materials, where isotopic labeling can influence physical properties like conductivity or stability.
• NMR Spectroscopy Standard: Acts as a valuable reference compound in Nuclear Magnetic Resonance (NMR) spectroscopy due to its distinct deuterium signature.

Basic Information

Product Name	cis-1,2,3,6-Tetrahydrophthalimide (Ring-D6)
CAS No.	203578-24-9
Molecular Formula	C8D6H2NO2
Molecular Weight	154.18 g/mol
Synonyms	1,2,3,6-Tetrahydro-cis-phthalimide-d6; 4,5,6,7-Tetradeutero-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione; cis-1,2,3,6-Tetrahydrophthalimide-d6; 3a,4,7,7a-Tetrahydro-1H-isoindole-1,3(2H)-dione-4,5,6,7-d4; Deuterated cis-Tetrahydrophthalimide; D6-cis-THPI; (3aR,7aS)-rel-3a,4,7,7a-Tetrahydro-1H-isoindole-1,3(2H)-dione-4,5,6,7-d4
EINECS	Contact for details

Quality Control

Our cis-1,2,3,6-Tetrahydrophthalimide (Ring-D6) is manufactured under strict quality control protocols to ensure high isotopic purity and chemical integrity, meeting the stringent requirements of research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic enrichment (D-atom %), and impurity profiles. We adhere to relevant industry standards for fine chemicals and stable isotope-labeled compounds.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D-atom %)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.