Description

5-Thiazolecarbonyl Chloride, 4-(Difluoromethyl)-2-Methyl- (9Ci) is a high-value, specialized heterocyclic building block featuring a reactive acid chloride group and a difluoromethyl substituent. This compound is critically important for its role in the synthesis of novel, complex molecules, particularly in advanced pharmaceutical research and agrochemical development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise, high-purity intermediates for constructing thiazole-based active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, anti-infectives, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides where the thiazole moiety and fluorine atoms enhance biological activity and environmental stability.
• Chemical Biology & Proteomics: Serves as a reactive handle for labeling or modifying biomolecules in probe development and activity-based protein profiling (ABPP) studies.
• Material Science Research: Employed as a monomer or cross-linking agent in the synthesis of specialized polymers and advanced organic materials with unique electronic or optical properties.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses (CROs/CMOs) producing bespoke compounds for client R&D pipelines.

Basic Information

Product Name	5-Thiazolecarbonyl Chloride, 4-(Difluoromethyl)-2-Methyl- (9Ci)
CAS No.	203448-82-2
Molecular Formula	C6H4ClF2NOS
Molecular Weight	195.62 g/mol
Synonyms	4-(Difluoromethyl)-2-methylthiazole-5-carbonyl chloride; 2-Methyl-4-(difluoromethyl)thiazole-5-carbonyl chloride; 4-(Difluoromethyl)-2-methyl-1,3-thiazole-5-carbonyl chloride; 5-Carbonyl chloride-4-(difluoromethyl)-2-methylthiazole; Thiazole-5-carbonyl chloride, 4-(difluoromethyl)-2-methyl-
EINECS	Contact for details

Quality Control

Every batch of 5-Thiazolecarbonyl Chloride, 4-(Difluoromethyl)-2-Methyl- (9Ci) is produced and tested under strict quality management protocols to ensure consistency and reliability for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by HPLC/NMR), identity confirmation, and moisture content. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and documentation for regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.