Description

2-(2-Chloro-Acetylamino)-5,6-Dihydro-4H-Cyclopenta[B]Thiophene-3-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate with the CAS number 203385-15-3. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fused heterocyclic scaffolds. It is essential for R&D and production teams in the pharmaceutical and fine chemical industries who require reliable, high-quality intermediates for scale-up and process development.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and anti-inflammatory pathways.
• Organic Synthesis Building Block: Used in research to construct complex fused-ring systems containing thiophene and cyclopentane motifs.
• Agrochemical Research: Serves as a starting material for developing new active ingredients with potential herbicidal or insecticidal properties.
• Material Science: Investigated for the development of specialty chemicals and functional materials due to its unique molecular architecture.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects.
• Academic & Industrial R&D: Utilized in laboratories for methodological studies and the exploration of new chemical reactions.

Basic Information

Product Name	2-(2-Chloro-Acetylamino)-5,6-Dihydro-4H-Cyclopenta[B]Thiophene-3-Carboxylic Acid Ethyl Ester
CAS No.	203385-15-3
Molecular Formula	C13H14ClNO3S
Molecular Weight	299.77 g/mol
Synonyms	Ethyl 2-[(2-chloroacetyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate; 2-(2-Chloroacetamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic Acid Ethyl Ester; 2-(2-Chloroacetylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic Acid Ethyl Ester; 203385-15-3; Cyclopenta[b]thiophene-3-carboxylic acid, 2-[(2-chloroacetyl)amino]-5,6-dihydro-4H-, ethyl ester
EINECS	Contact for details

Quality Control

Our 2-(2-Chloro-Acetylamino)-5,6-Dihydro-4H-Cyclopenta[B]Thiophene-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.