Description

(2,2'-Dimethyl-[1,1'-Biphenyl]-3,3'-Diyl)Dimethanol is a high-purity biphenyl derivative featuring dual hydroxymethyl functional groups, making it a versatile and valuable chiral building block in advanced organic synthesis. Its rigid, axially chiral structure is critical for constructing complex molecular architectures with precise stereochemistry. This compound is essential for research and development in the pharmaceutical and fine chemical industries, particularly for applications requiring high enantiomeric purity.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting central nervous system and cardiovascular diseases.
• Ligand Synthesis: Used to construct sophisticated chiral ligands for asymmetric catalysis, including phosphines and N-heterocyclic carbenes (NHCs).
• Material Science Monomer: Acts as a monomer for producing specialty polymers and liquid crystals, where its biphenyl core contributes to thermal stability and optical properties.
• Agrochemical Research: Employed in developing novel, enantiomerically pure agrochemicals such as herbicides and fungicides.
• Supramolecular Chemistry: Utilized as a building block for creating chiral hosts in molecular recognition and sensor development.
• Academic & R&D: A valuable tool for methodological development in organic chemistry and stereoselective synthesis at research institutions.

Basic Information

Product Name	(2,2'-Dimethyl-[1,1'-Biphenyl]-3,3'-Diyl)Dimethanol
CAS No.	203379-81-1
Molecular Formula	C16H18O2
Molecular Weight	242.31 g/mol
Synonyms	3,3'-Bis(hydroxymethyl)-2,2'-dimethylbiphenyl; 2,2'-Dimethylbiphenyl-3,3'-dimethanol; Biphenyl-3,3'-dimethanol, 2,2'-dimethyl-; (3,3'-Biphenyldiyl)dimethanol, 2,2'-dimethyl-; 2,2'-Dimethyl-3,3'-biphenyldimethanol; BINOL derivative, dimethyl-substituted; Axially chiral diol
EINECS	Contact for details

Quality Control

Our (2,2'-Dimethyl-[1,1'-Biphenyl]-3,3'-Diyl)Dimethanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, to ensure it meets the high-purity standards required for sensitive synthetic applications. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider the use of a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.