Description

n-Fmoc-(R)-1-Mercapto-2-Propanamine is a high-purity, chiral building block featuring both a thiol and a primary amine group, each protected for selective deprotection. This compound is essential for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics, enabling precise control over molecular architecture. It is primarily utilized by researchers and manufacturers in pharmaceutical development, particularly for creating novel therapeutic agents and advanced bioconjugates.

Application

• Peptide Synthesis: A key chiral intermediate for introducing cysteine-like residues and constructing disulfide bridges in synthetic peptides.
• Pharmaceutical Research: Used in the development of active pharmaceutical ingredients (APIs) and drug candidates targeting various diseases.
• Bioconjugation: Facilitates the site-specific attachment of peptides to proteins, antibodies, or other biomolecules for diagnostic and therapeutic applications.
• Combinatorial Chemistry: Serves as a versatile building block in libraries for high-throughput screening to identify new bioactive compounds.
• Material Science: Employed in the synthesis of functionalized polymers and surfaces with specific thiol-reactive properties.

Basic Information

Product Name	n-Fmoc-(R)-1-Mercapto-2-Propanamine
CAS No.	202751-94-8
Molecular Formula	C₁₈H₁₉NO₃S
Molecular Weight	329.41 g/mol
Synonyms	Fmoc-Cys(Me)-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-mercaptobutanoic Acid; Fmoc-Cys(Me)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-mercapto-D-valine; Fmoc-D-Cys(Me)-OH; Fmoc-S-methyl-D-cysteine; (R)-2-(Fmoc-amino)-3-(methylthio)propanoic Acid; N-α-Fmoc-S-methyl-D-cysteine
EINECS	Contact for details

Quality Control

Our n-Fmoc-(R)-1-Mercapto-2-Propanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.