Description

Tris-D11 is a deuterated analog of Tris(hydroxymethyl)aminomethane, a fundamental biochemical buffer. This isotopically labeled compound is essential for applications requiring high sensitivity and minimal background interference, such as nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. It is a critical reagent for researchers and manufacturers in pharmaceutical development, analytical chemistry, and structural biology, where precise molecular tracking and analysis are paramount.

Application

• NMR Spectroscopy Solvent & Internal Standard: Serves as a deuterated solvent and chemical shift reference in proton and carbon NMR studies.
• Mass Spectrometry (MS): Used as an internal standard for quantitative MS analysis to ensure accuracy and reproducibility in metabolite and protein studies.
• Biochemical Research & Protein Crystallography: Provides a stable, non-exchangeable deuterium source for buffer preparation in structural studies of proteins and nucleic acids.
• Pharmaceutical Development: Employed in drug metabolism and pharmacokinetics (DMPK) studies to trace the fate of drug molecules using isotope labeling techniques.
• Deuterated Compound Synthesis: Acts as a key starting material or intermediate for the synthesis of more complex deuterated chemicals and active pharmaceutical ingredients (APIs).
• Analytical Method Development: Utilized in developing and validating sensitive analytical methods where standard Tris would cause interference.

Basic Information

Product Name	Tris-D11
CAS No.	202656-13-1
Molecular Formula	C4D11NO3
Molecular Weight	125.19 g/mol
Synonyms	Tris(trideuteriomethyl)deuteriomethanamine; Deuterated Tris; Tris(hydroxymethyl-d3)aminomethane-d2; 2-Amino-2-(hydroxymethyl)-1,3-propanediol-1,1,1,3,3,3-d6,2,2-d2; THAM-D11; Trometamol-D11; TRIS-D11; Tris base-D11
EINECS	Contact for details

Quality Control

Our Tris-D11 is manufactured under strict quality systems to ensure high isotopic purity and chemical consistency, critical for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (D-atom %), chemical purity, and absence of critical impurities. We adhere to cGMP principles where applicable to support regulatory filings in pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Deuterium Content (NMR)	≥ 98 atom % D
Assay (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.