Description

Z-Gly-D-Trp-Oh is a protected dipeptide building block, specifically the benzyloxycarbonyl (Z) derivative of the Glycyl-D-Tryptophan sequence. This compound is a critical intermediate in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control for research and development. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on peptide-based drug discovery, hormone research, and biochemical studies.

Application

• Pharmaceutical Intermediate: Key building block for the solid-phase and solution-phase synthesis of therapeutic peptides targeting GPCRs and other biological pathways.
• Biochemical Research: Used in studies of peptide structure-activity relationships (SAR), enzyme substrates, and receptor-ligand interactions.
• Peptidomimetic Development: Serves as a precursor for creating non-natural peptide analogs with enhanced stability and bioavailability.
• Neuropeptide Synthesis: Integral in the preparation of tryptophan-containing neuropeptides and hormone analogs for neurological and endocrinological research.
• Custom Peptide Services: A fundamental reagent for CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) offering bespoke peptide synthesis.
• Academic Research: Employed in university laboratories for teaching advanced peptide chemistry and conducting foundational biomedical research.

Basic Information

Product Name	Z-Gly-D-Trp-Oh
CAS No.	202595-75-3
Molecular Formula	C21H21N3O5
Molecular Weight	395.41 g/mol
Synonyms	N-CBZ-Glycyl-D-tryptophan; Benzyloxycarbonylglycyl-D-tryptophan; Z-Gly-D-Trp-OH; CBZ-Gly-D-Trp-OH; N-[(Benzyloxy)carbonyl]glycyl-D-tryptophan; (R)-2-((2-((Benzyloxy)carbonylamino)acetamido)-3-(1H-indol-3-yl)propanoic acid; Glycine, N-[(phenylmethoxy)carbonyl]-, (R)-tryptophan derivative
EINECS	Contact for details

Quality Control

Our Z-Gly-D-Trp-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC for purity, NMR and IR for structural confirmation, and optical rotation for chiral integrity. We support compliance with cGMP guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.