Description

6H-Thieno[3,2-F][1,2,4]Triazolo[4,3-A][1,4]Diazepine-6-Acetic Acid, 4-(4-Chlorophenyl)-2,3,9-Trimethyl-, (6S)- is a high-purity, complex heterocyclic compound with a defined stereochemistry, serving as a critical advanced pharmaceutical intermediate. Its value lies in its role as a sophisticated building block for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and metabolic disorder applications. This compound is essential for pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers seeking to develop next-generation active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel benzodiazepine and thienotriazolodiazepine analogs for preclinical and clinical research.
• Neurological Drug Discovery: Used in the development of potential therapeutic agents targeting GABAA receptors for conditions like anxiety, insomnia, and seizures.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in API manufacturing.
• Process Chemistry Development: Used to develop and scale up efficient, asymmetric synthetic routes for complex heterocyclic systems.
• Biochemical Tool Compound: Utilized in vitro and in vivo studies to investigate specific biological pathways and receptor interactions.

Basic Information

Product Name	6H-Thieno[3,2-F][1,2,4]Triazolo[4,3-A][1,4]Diazepine-6-Acetic Acid, 4-(4-Chlorophenyl)-2,3,9-Trimethyl-, (6S)-
CAS No.	202592-23-2
Molecular Formula	C19H17ClN4O2S
Molecular Weight	400.88 g/mol
Synonyms	(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid; L-838,417 carboxylic acid derivative; Thienotriazolodiazepine acetic acid derivative; (S)-4-(p-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f]-s-triazolo[4,3-a][1,4]diazepine-6-acetic acid; GABAA receptor α-subunit selective ligand intermediate
EINECS	Contact for details

Quality Control

Our 6H-Thieno[3,2-F][1,2,4]Triazolo[4,3-A][1,4]Diazepine-6-Acetic Acid, 4-(4-Chlorophenyl)-2,3,9-Trimethyl-, (6S)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and comprehensive identification and assay methods, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (6S-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.