Description

D-[2-2H]Ribose is a stable isotope-labeled analog of the essential pentose sugar, D-ribose, specifically deuterated at the 2-position. This precise labeling makes it an indispensable tool for advanced research in metabolic pathway tracing and structural elucidation using techniques like NMR spectroscopy and mass spectrometry. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in drug discovery, metabolic studies, and the development of diagnostic assays.

Application

• Metabolic Pathway Analysis: Used as a tracer to study the biosynthesis and catabolism of nucleotides, cofactors, and glycans in living systems.
• NMR Spectroscopy Internal Standard: Serves as a non-radioactive internal standard for quantitative NMR analysis due to its distinct spectroscopic signature.
• Mass Spectrometry (MS) Studies: Employed in MS-based proteomics and metabolomics for precise quantification and to track the incorporation of labeled precursors.
• Pharmaceutical Research: Critical in the development and testing of antiviral and anticancer nucleoside analogs, helping to understand drug mechanisms and metabolism.
• Biochemical Reaction Mechanism Studies: Aids in elucidating enzyme mechanisms, particularly those of isomerases and kinases involved in carbohydrate metabolism.
• Stable Isotope-Labeled Reference Material: Used in the production of certified reference materials (CRMs) for analytical method validation and quality control.

Basic Information

Product Name	D-[2-2H]Ribose
CAS No.	202480-69-1
Molecular Formula	C5H9D1O5
Molecular Weight	151.13 g/mol
Synonyms	2-Deuterio-D-ribose; D-Ribose-2-d; (2R,3R,4R)-2,3,4,5-Tetrahydroxypentanal-2-d; Deuterated D-ribose; Stable Isotope Labeled D-ribose; [2-2H]-D-Ribofuranose; Ribose-d1; D-Ribose (2-2H)
EINECS	Contact for details

Quality Control

Every batch of our D-[2-2H]Ribose is produced and analyzed under strict quality management protocols to ensure high isotopic and chemical purity, critical for sensitive research applications. We provide comprehensive Certificates of Analysis (COA) detailing parameters such as isotopic enrichment (deuterium content), chemical purity by HPLC, and specific optical rotation. Our quality systems are designed to support research requiring traceability and reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent uptake of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.