Description

1-Bromo-5-Chloro-3-Fluoro-2-Iodobenzene is a highly functionalized halogenated benzene derivative, a key building block in advanced organic synthesis. Its precise arrangement of four distinct halogens makes it an exceptionally versatile intermediate for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug candidates, particularly in medicinal chemistry for structure-activity relationship (SAR) studies.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and pesticides, where halogen diversity is crucial for bioactivity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and liquid crystals.
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed reactions (e.g., Suzuki, Stille, Sonogashira) due to the differential reactivity of its halogen atoms.
• Chemical Library Development: Employed in high-throughput and combinatorial chemistry to generate diverse compound libraries for screening.
• Ligand and Catalyst Preparation: Used to synthesize sophisticated ligands for catalysis and molecular recognition applications.

Basic Information

Product Name	1-Bromo-5-Chloro-3-Fluoro-2-Iodobenzene
CAS No.	201849-16-3
Molecular Formula	C6H2BrClFI
Molecular Weight	335.34 g/mol
Synonyms	2-Bromo-4-chloro-6-fluoro-1-iodobenzene; 2-Iodo-3-fluoro-5-chlorobromobenzene; 3-Fluoro-5-chloro-2-iodobromobenzene; Benzene, 1-bromo-5-chloro-3-fluoro-2-iodo-; 1-Iodo-2-bromo-4-chloro-6-fluorobenzene; 5-Chloro-3-fluoro-2-iodobromobenzene; 2-Bromo-6-fluoro-4-chloro-1-iodobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-5-Chloro-3-Fluoro-2-Iodobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat sources and incompatible materials. Due to its light-sensitive nature, handling should be performed under subdued light or in amber glass containers when possible.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.