Description

1-Bromo-3-Chloro-2,4-Difluorobenzene is a high-purity halogenated benzene derivative, serving as a critical building block in advanced organic synthesis. Its precise substitution pattern makes it an invaluable intermediate for constructing complex molecules where specific halogen atoms are required for subsequent functional group transformations. This compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty materials sectors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing difluorobenzene and halogen-substituted aromatic cores.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the halogen atoms act as leaving groups or direct further substitution.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated aromatic components in electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination due to the presence of bromine and chlorine.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating complex molecular architectures.
• Polymer Modification: Used to introduce halogenated aromatic units into polymer backbones to alter physical properties such as thermal stability and refractive index.

Basic Information

Item	Details
Product Name	1-Bromo-3-Chloro-2,4-Difluorobenzene
CAS No.	201849-13-0
Molecular Formula	C6H2BrClF2
Molecular Weight	227.44 g/mol
Synonyms	2,4-Difluoro-1-bromo-3-chlorobenzene; 3-Chloro-1-bromo-2,4-difluorobenzene; 1-Bromo-3-chloro-2,4-difluorobenzol; Benzene, 1-bromo-3-chloro-2,4-difluoro-; 2,4-Difluoro-3-chlorobromobenzene; 3-Bromo-1-chloro-2,4-difluorobenzene (isomer check); BCFB (abbreviation)
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-Chloro-2,4-Difluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure it meets the high standards required for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, supporting compliance with cGMP and ISO 9001 guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are properly sealed and stored upright away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.