Description

5-Amino-2-Boc-1,2,3,4-Tetrahydroisoquinoline is a high-purity, protected amine derivative of the tetrahydroisoquinoline scaffold, serving as a critical building block in advanced organic synthesis. Its value lies in providing a reactive amino group shielded by the acid-labile Boc (tert-butoxycarbonyl) protecting group, enabling precise, multi-step synthetic sequences. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active pharmaceutical ingredients (APIs) and complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting neurological disorders and cardiovascular diseases.
• Agrochemical Research: Used in the development of new pesticides and herbicides that leverage the tetrahydroisoquinoline core for biological activity.
• Organic Synthesis Building Block: Employed in multi-step synthetic routes to construct complex nitrogen-containing heterocycles for material science and fine chemicals.
• Peptidomimetics & Medicinal Chemistry: Integral for creating peptide analogs and small molecule libraries in drug discovery programs.
• Academic & R&D Laboratories: Serves as a standard reagent for methodological development and chemical education in advanced organic chemistry.

Basic Information

Product Name	5-Amino-2-Boc-1,2,3,4-Tetrahydroisoquinoline
CAS No.	201150-73-4
Molecular Formula	C14H20N2O2
Molecular Weight	248.32 g/mol
Synonyms	tert-Butyl (5-Amino-3,4-dihydroisoquinolin-2(1H)-yl)carboxylate; 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-5-amine; 5-Amino-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline; 2-Boc-5-amino-1,2,3,4-tetrahydroisoquinoline; 5-Amino-2-Boc-THIQ; Boc-5-ATIQ; 201150-73-4
EINECS	Contact for details

Quality Control

Every batch of 5-Amino-2-Boc-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing purity (typically ≥97% by HPLC), identity confirmation, and impurity profile is supplied with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.