Description

2-(Boc-Amino)-3-(Diethoxyphosphoryl)Propionic Acid is a sophisticated, multi-functional building block in organic synthesis, combining a protected amine group with a phosphonate moiety. This unique structure makes it a critical intermediate for the efficient construction of complex molecules, particularly in peptide and peptidomimetic chemistry. It is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing peptide analogs, enzyme inhibitors, and drug candidates with modified backbone structures.
• Peptidomimetic Synthesis: Enables the incorporation of non-hydrolyzable phosphonate isosteres into peptide chains to enhance metabolic stability and biological activity.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators that mimic natural peptides.
• Chemical Biology Probes: Serves as a precursor for creating activity-based probes and affinity labels to study enzyme mechanisms and protein interactions.
• Ligand Development: Useful for constructing chelating agents and complexing ligands in coordination chemistry and catalysis.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for CDMOs and fine chemical suppliers offering bespoke synthesis services.

Basic Information

Product Name	2-(Boc-Amino)-3-(Diethoxyphosphoryl)Propionic Acid
CAS No.	200640-83-1
Molecular Formula	C₁₂H₂₄NO₇P
Molecular Weight	325.30 g/mol
Synonyms	3-(Diethoxyphosphoryl)-2-[(tert-butoxycarbonyl)amino]propanoic Acid; N-Boc-3-phosphonolalanine Diethyl Ester; 2-[(tert-Butoxycarbonyl)amino]-3-(diethoxyphosphoryl)propanoic Acid; Boc-Ppa(OEt)₂-OH; Boc-β-phosphonoalanine Diethyl Ester; (2R/S)-2-[(tert-Butoxycarbonyl)amino]-3-(diethoxyphosphoryl)propionic Acid; N-(tert-Butoxycarbonyl)-3-(diethoxyphosphoryl)-DL-alanine
EINECS	Contact for details

Quality Control

Our production of 2-(Boc-Amino)-3-(Diethoxyphosphoryl)Propionic Acid adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, NMR, and MS for comprehensive characterization. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profile is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.